MLB Home Run Predictions Today: HR Prop Bets for Wednesday, May 27

Shea Langeliers, Bryce Harper and Ernie Clement headline Wednesday’s top MLB home run prop bets with huge upside.

by Andrew Phelps

May 27, 2026

Philadelphia Phillies first baseman Bryce Harper (3) celebrates

David Frerker-Imagn Images

It’s "Wednesday Wallop Watch," and the home run spots are lining up beautifully across the slate. We have pitchers bringing fly-ball problems and shaky splits into dangerous matchups, while several hitters are either scorching hot lately or already own strong history against tonight’s starter.

We have Shea Langeliers facing a pitcher he’s already taken deep twice, Bryce Harper bringing elite power numbers into a matchup he’s already crushed before, and Ernie Clement staying hot against a pitcher getting tagged badly by right-handed bats. If you’re chasing long balls, these are bats with serious moonshot upside.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Best NRFI and YRFI MLB Bets for Wednesday, May 27

Best Home Run Props Today

Shea Langeliers Home Run Bet (+338)

Langeliers is 3-for-23 against Logan Gilbert in his career, but two of those hits have been home runs. He leads the Athletics with 13 home runs this season with 10 coming against right-handed pitching like Gilbert, who also has been giving up plenty of fly balls while allowing 11 home runs already this year.

Bryce Harper Home Run Bet (+373)

Harper has mashed right-handed pitching this season with 10 of his 13 home runs coming against righties, and now he gets a matchup he’s already crushed against Walker Buehler. Harper is 4-for-6 lifetime off Buehler with three doubles and a home run already. Buehler still gives up plenty of fly balls too, while Harper continues posting elite hard-hit numbers.

Ernie Clement Home Run Bet (+840)

Clement comes into Wednesday night with home runs in back-to-back games, and now he gets Eury Perez, who has really struggled keeping the ball in the yard. Perez has already allowed 11 home runs this season, including nine to right-handed hitters, and he owns a 7.03 ERA on the road. Four of Clement’s five home runs this season have also come at home, making this a really fun long-shot home run play.