MLB Home Run Predictions Today: HR Prop Bets for Tuesday, May 5

Elly De La Cruz, Jose Ramirez and JJ Wetherholt headline Tuesday’s best HR prop bets with strong matchups and big-time power upside.

by Athlon Sports
MLB Home Run Predictions Today: HR Prop Bets for Tuesday, May 5

Cincinnati Reds shortstop Elly de la Cruz (44) follows through on a two-run home run

Sam Greene/The Enquirer / USA TODAY NETWORK via Imagn Images

It’s the "Tuesday Trot Tracker," and this slate is packed with hitters in prime spots to do damage. With pitchers allowing plenty of elevated contact and power bats trending up, the conditions are right for balls to leave the yard in a hurry.

We have Elly De La Cruz in a matchup against a pitcher giving up plenty of long balls, Jose Ramirez stepping into a favorable split against a lefty he’s already handled, and JJ Wetherholt bringing elite contact and rising power into a matchup against a fly-ball-prone arm. If you’re chasing dingers, these are prime bats to go yard.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Best Home Run Props Today

Elly De La Cruz Home Run Bet (+448)

Power potential is high for De La Cruz in this matchup with Jameson Taillon. Taillon has been prone to the long ball, allowing nine home runs, and his four-seamer has produced a 54.5% fly-ball rate, well above league average. That profile creates opportunities, especially for left-handed hitters, who have already taken him deep four times. De La Cruz thrives from that side and has had success in this matchup, going 5-for-14 with two home runs. With the ball getting elevated, this is a strong setup for his power to show up.

Jose Ramirez Home Run Bet(+411)

Power could show up for Ramirez in this matchup against Noah Cameron. Even in a down year, Ramirez has continued to hit lefties well and has already had success here, going 4-for-8 with a home run. Cameron has been vulnerable, allowing five home runs with a high fly-ball rate that leads to elevated contact. Right-handed hitters are batting .304 against him, which plays into Ramirez’s strengths. This setup gives him a strong chance to leave the yard.

JJ Wetherholt Home Run Bet (+790)

A strong power spot is shaping up for Wetherholt against Brandon Sproat. Wetherholt has impressed early with elite contact and hard-hit metrics, including a recent stretch near 60% hard contact. He’s already shown power vs. right-handers, with five home runs in those matchups. Sproat has a fly-ball-heavy profile and has struggled against lefties, who have four home runs and are hitting .300 with a .600 slugging percentage. With the ball getting lifted, this is a spot where Wetherholt’s power can show up.

2026 MLB HR Leaders

  • OF Aaron Judge, New York Yankees (14)
  • 1B Munetaka Murakami, Chicago White Sox (13)
  • DH Yordan Alvarez, Houston Astros (12)
  • 1B Ben Rice, New York Yankees (12)
  • 1B Matt Olson, Atlanta Braves (11)
  • OF Kyle Schwarber, Philadelphia Phillies (11)
  • OF Mickey Moniak, Colorado Rockies (11)
Published:
by Athlon Sports

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