MLB Home Run Predictions Today: Best HR Prop Bets for Wednesday, Sept. 16

Keibert Ruiz, Ben Rice and Mookie Betts headline Wednesday’s MLB home run picks with favorable matchups and strong long-ball potential.

by Andrew Phelps

Sep 16, 2026

Washington Nationals catcher Keibert Ruiz (20) celebrates

David Frerker-Imagn Images

It’s “Wednesday Wallop Watch,” with three bats ready to send some baseballs sightseeing. Keibert Ruiz gets Zack Wheeler, whom he’s already taken deep three times. Ben Rice faces Zebby Matthews, who’s allowed four homers over his last two starts. Mookie Betts draws Andrew Abbott after crushing four bombs already this month.

Ruiz, Rice and Betts have the history, power and pitching matchups to turn Wednesday into another busy night in the bleachers.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Best MLB First-Inning Predictions (NRFI/YRFI) for Wednesday, Sept. 16

Best Home Run Props Today

Keibert Ruiz Home Run Bet (+1000)

Ruiz isn’t exactly a regular on the home run menu, but Wednesday is a fun spot to swing for some value. Ruiz has given Zack Wheeler problems, going 8-for-30 with three bombs and two doubles against him. Wheeler has surrendered 13 of his 20 homers to lefties and six over his last five starts. Ruiz gets to hit left-handed here, and I’m taking a shot on homer No. 11.

Ben Rice Home Run Bet (+482)

Rice has the power dial cranked back up, launching three September bombs and sitting just two shy of 40. Wednesday brings Zebby Matthews, a pitcher Rice has already tagged while going 4-for-8 with a homer and a double. Matthews has coughed up four bombs over his last two starts, while 28 of Rice’s 38 have come against righties.

Mookie Betts Home Run Bet (+508)

Betts has officially found his September swagger, batting .319 with four bombs and a .660 slugging percentage this month. Now he gets his first crack at Andrew Abbott, who’s been serving up souvenirs lately. The lefty has allowed six homers over his last three starts, with 16 of his 24 bombs coming against righties. Mookie is rolling, Abbott is vulnerable, and I’m riding Betts for a long ball Wednesday.