MLB Home Run Predictions Today: Best HR Prop Bets for Tuesday, Sept. 22

Austin Wells, Nolan Arenado and Jose Altuve headline Tuesday’s home run picks with hot bats and favorable pitching matchups.

by Andrew Phelps

Sep 22, 2026

Houston Astros designated hitter Jose Altuve (27) crosses home plate

Erik Williams-Imagn Images

It’s “Tuesday Tater Targets,” with three bats ready to send some baseballs sightseeing. Austin Wells gets Nick Martinez, whom he’s already taken deep twice in just five at-bats. Nolan Arenado faces Kyle Freeland after crushing six homers already this month. Jose Altuve draws Logan Gilbert, whom he’s tagged for two homers and seven doubles in his career.

Wells, Arenado and Altuve have the history, hot bats and pitching matchups to make Tuesday a busy night in the bleachers.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Best MLB First-Inning Predictions (NRFI/YRFI) for Tuesday, Sept. 22

Best Home Run Props Today

Austin Wells Home Run Bet (+577)

Wells is heating up, crushing three homers in his last six games to push his season total to 13. He’s also had Nick Martinez’s number, going 2-for-5 against him with both hits leaving the yard. Martinez has surrendered 21 homers this season, including 12 to left-handed bats and three in September. Wells has the hot bat and matchup history on his side.

Nolan Arenado Home Run Bet (+404)

Arenado is bringing plenty of power into Tuesday, with six September homers and 27 on the season. Now he gets Kyle Freeland, who has struggled against right-handed bats. Twenty-four of the lefty’s 27 homers allowed have come against righties, and he surrendered three bombs in his last start. Arenado is swinging a hot bat, and the matchup is hard to ignore.

Jose Altuve Home Run Bet (+800)

Altuve is coming off homer No. 16 on Sunday, and Tuesday brings a familiar matchup against Logan Gilbert. Altuve is 15-for-40 lifetime against Gilbert with seven doubles, two homers and a .700 slugging percentage. Gilbert has also been giving up plenty of long balls lately, surrendering six over his last three starts and 28 in 30 outings this season.