MLB Home Run Predictions Today: Best HR Prop Bets for Tuesday, Sept. 15

Pete Alonso, Elly De La Cruz and Mike Trout bring favorable matchups and plenty of power upside to Tuesday’s MLB home run picks.

by Athlon Sports
MLB Home Run Predictions Today: Best HR Prop Bets for Tuesday, Sept. 15

Cincinnati Reds shortstop Elly De La Cruz (44) hits a single

Benny Sieu-Imagn Images

It’s “Tuesday Tater Targets,” with three big bats ready to put some baseballs in the seats. Pete Alonso gets Sean Manaea, who’s allowed seven homers over his last five starts. Elly De La Cruz faces Yoshinobu Yamamoto after crushing six bombs already this month. Mike Trout draws Logan Gilbert, whom he’s taken deep twice in just 11 career at-bats.

Alonso, De La Cruz and Trout have the power, history and matchups to make the bleachers busy Tuesday.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

  • Best MLB First-Inning Predictions (NRFI/YRFI) for Tuesday, Sept. 15

Best Home Run Props Today

Pete Alonso Home Run Bet (+303)

Alonso is chasing 40 bombs, and Tuesday brings a pitcher he’s already taken for a ride. The Polar Bear went deep against Sean Manaea two meetings ago, and the lefty has been serving up souvenirs lately, allowing seven homers over his last five starts. Sixteen of Manaea’s 21 bombs allowed have come against righties.

Elly De La Cruz Home Run Bet (+468)

De La Cruz has turned September into his personal highlight reel, batting .419 with six bombs and even going deep five straight days last week. Seventeen of his 27 homers have come from the left side against righties, and he’s already taken Yoshinobu Yamamoto yard before. Yamamoto has coughed up four homers over his last three starts.

Mike Trout Home Run Bet (+429)

Trout sees an old AL West acquaintance Tuesday, and he’s made Logan Gilbert pay before. Trout is 4-for-11 with two bombs against the Mariners righty and just went deep Friday for homer No. 21. Seventeen of those have come against right-handed pitching, while Gilbert has allowed more homers to righties than lefties.

2026 MLB HR Leaders

  • DH Kyle Schwarber, Philadelphia Phillies (44)
  • CF Pete Crow-Armstrong, Chicago Cubs (41)
  • 3B Junior Caminero, Tampa Bay Rays (40)
  • 1B Matt Olson, Atlanta Braves (39)
  • DH Yordan Alvarez, Houston Astros (38)
  • C Hunter Goodman, Colorado Rockies (38)
  • 1B Ben Rice, New York Yankees (38)
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by Athlon Sports

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