MLB Home Run Predictions Today: Best HR Prop Bets for Monday, Sept. 7

Coby Mayo, Bryce Harper and Rafael Devers highlight Monday’s MLB home run picks with favorable matchups and plenty of long-ball upside.

by Athlon Sports
MLB Home Run Predictions Today: Best HR Prop Bets for Monday, Sept. 7

Baltimore Orioles third baseman Coby Mayo (16) receives congratulations from teammates

Rick Osentoski-Imagn Images

It’s “Labor Day Launch Party,” with three sluggers ready to provide some holiday fireworks. Coby Mayo gets Joey Cantillo, who’s allowed 13 homers to righties. Bryce Harper faces Grant Holmes, whom he’s already taken deep in his career. Rafael Devers draws Michael McGreevy after crushing five homers in his first six September games.

Mayo, Harper and Devers have the splits, history and hot bats to send one into the seats Monday.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

  • Best MLB First-Inning Predictions (NRFI/YRFI) for Monday, Sept. 7

Best Home Run Props Today

Coby Mayo Home Run Bet (+528)

Labor Day could bring some fireworks from Coby Mayo, who’s still searching for his first September homer. Mayo has 19 bombs this season, with 15 coming against lefties. That makes Joey Cantillo an inviting matchup, as 13 of the southpaw’s 16 homers allowed have come against right-handed hitters. Cantillo was also tagged for a homer in his last start.

Bryce Harper Home Run Bet (+421)

Harper’s home run swing has been quiet since Aug. 26, but Monday’s matchup is begging for some Labor Day fireworks. Harper has crushed 23 of his 27 bombs against righties, while Grant Holmes has surrendered 12 homers to left-handed hitters. Harper has also taken Holmes deep before, going 2-for-4 against him.

Rafael Devers Home Run Bet (+600)

Devers has turned the power dial all the way up, crushing 28 homers since the beginning of June and five in his first six September games. Now he gets Michael McGreevy, who’s surrendered 13 of his 20 homers to left-handed hitters. Even better, Devers has already torched McGreevy, going 3-for-5 with two bombs against him. I’m riding the red-hot Devers to keep launching baseballs Monday.

2026 MLB HR Leaders

  • DH Kyle Schwarber, Philadelphia Phillies (42)
  • CF Pete Crow-Armstrong, Chicago Cubs (40)
  • 3B Junior Caminero, Tampa Bay Rays (38)
  • DH Yordan Alvarez, Houston Astros (38)
  • 1B Matt Olson, Atlanta Braves (37)
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by Athlon Sports

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