MLB Home Run Predictions Today: Best HR Prop Bets for Friday, Sept. 25

Bryce Harper, Munetaka Murakami and Julio Rodriguez headline Friday’s home run picks with favorable splits and strong matchup history.

by Athlon Sports
MLB Home Run Predictions Today: Best HR Prop Bets for Friday, Sept. 25

Philadelphia Phillies outfielder Bryce Harper in the first inning

Mark J. Rebilas-Imagn Images

It’s “Friday Fly Ball Frenzy,” with three bats ready to send some souvenirs into the seats. Bryce Harper gets Freddy Peralta, whom he’s already taken deep three times. Munetaka Murakami faces Tomoyuki Sugano, who’s allowed 21 homers to left-handed bats this season. Julio Rodriguez draws Reid Detmers, whom he’s hitting .400 against in his career.

Harper, Murakami and Rodriguez have the history, splits and pitching matchups to make Friday a busy night in the bleachers.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

  • Best MLB First-Inning Predictions (NRFI/YRFI) for Friday, Sept. 25

Best Home Run Props Today

Bryce Harper Home Run Bet (+477)

Harper has only one September homer, but Friday gives him a good chance to add another. Harper is 5-for-16 against Freddy Peralta, with three homers and two doubles. Peralta has allowed 23 bombs this season, including 17 to left-handed hitters. Harper has also hit 24 of his 28 homers against righties.

Munetaka Murakami Home Run Bet (+404)

Murakami has crushed 33 homers in his rookie season, including four in September. He gets a great matchup Friday against Tomoyuki Sugano. Murakami has hit 26 of his bombs against righties, while Sugano has allowed 21 of his 31 homers to left-handed bats. Sugano has also surrendered four over his last three starts.

Julio Rodriguez Home Run Bet (+TBD)

Rodriguez has just one homer in September, but Friday gives him a good chance to change that against Reid Detmers. Rodriguez is 6-for-15 against the lefty with two doubles and a homer. Detmers has allowed 19 bombs this season, including 15 to right-handed hitters, and one in each of his last two starts.

2026 MLB HR Leaders

  • DH Kyle Schwarber, Philadelphia Phillies (45)
  • CF Pete Crow-Armstrong, Chicago Cubs (45)
  • 3B Junior Caminero, Tampa Bay Rays (41)
  • DH Yordan Alvarez, Houston Astros (41)
  • 1B Matt Olson, Atlanta Braves (41)
  • 1B Pete Alonso, Baltimore Orioles (41)
  • 1B Ben Rice, New York Yankees (41)
Published:
by Athlon Sports

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