MLB Home Run Predictions Today: Best HR Prop Bets for Friday, Aug. 21

Friday’s best home run bets feature Colton Cowser, Randal Grichuk and Ildemaro Vargas in matchups that could have baseballs flying into the seats.

by Andrew Phelps

Aug 21, 2026

Chicago White Sox designated hitter Randal Grichuk (34) celebrates

Horwedel-Imagn Images

It’s “Friday Fly Ball Frenzy,” and three hitters have matchups begging for a trip around the bases. Colton Cowser gets Freddy Peralta, who’s surrendered 15 of his 20 homers to lefties. Randal Grichuk draws Sean Manaea, a pitcher he’s already taken deep twice. Meanwhile, Ildemaro Vargas faces Nick Lodolo, who’s allowed 11 of his 12 homers to right-handed bats.

If you’re looking for Friday’s best home run props, Cowser, Grichuk and Vargas have the splits, history and matchups to leave the yard.

All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.

Best MLB First-Inning Predictions (NRFI/YRFI) for Friday, Aug. 21

Best Home Run Props Today

Colton Cowser Home Run Bet (+596)

Cowser is starting to find that sweet left-handed swing, already launching three homers in August. Ten of his 11 bombs this season have come against righties, and Friday brings a familiar target. Freddy Peralta has surrendered 15 of his 20 homers to left-handed bats and three already this month. Cowser has taken Peralta deep before, and this matchup is begging for an encore.

Randal Grichuk Home Run Bet (+513)

Grichuk sees a lefty Friday, and that’s usually when the fun begins. Eight of his 10 homers have come against southpaws, and he’s already taken Sean Manaea deep twice while going 6-for-19 against him. Manaea has served up 12 of his 16 bombs to righties and three over his last two starts.

Ildemaro Vargas Home Run Bet (+750)

Vargas is starting to find the launch button, crushing two homers over the last week. Six of his nine bombs have come against lefties, and he’s already taken Nick Lodolo deep in limited history. Lodolo has become a home run piñata lately, serving up four over his last three starts, while righties have crushed 11 of his 12 allowed this season.