Opening Day is finally here, and it’s one of the best days on the sports calendar. Welcome to a full slate of games, fresh starts, and plenty of betting opportunities as the long MLB season begins.
This article highlights five prop bets worth targeting. We have a Dodgers ace in a strong spot to dominate, a potential pitching duel in Philadelphia, and another arm with a favorable matchup to exploit. There’s also a young star ready to shine on Opening Day and help his team get off to a fast start.
All odds are from DraftKings Sportsbook and are subject to change. DraftKings does not sponsor this content.
Dodgers SP Yoshinobu Yamamoto 6+ Strikeouts (-120)
Yamamoto has made six-plus strikeouts routine, hitting the mark in 14 of his final 15 starts in 2025 with a 10.42 K/9. The Los Angeles Dodgers ace has stayed sharp into 2026 and dominated the Arizona Diamondbacks last season, posting seven, nine, and 10 Ks in three of the four matchups.
Rangers & Phillies Under 8 Total Runs (-115)
This sets up as a pitcher’s duel on Opening Day. Nathan Eovaldi (1.73 ERA in 2025) remains elite, while Cristopher Sanchez (2.50 ERA) anchors Philly. Both limit walks and hard contact, and each bullpen is solid. Even at hitter-friendly Citizens Bank Park, runs could be limited — especially if you grab 8.5.
Cubs SP Matthew Boyd 6+ Strikeouts (+140)
Boyd draws a favorable matchup against a Washington Nationals lineup that struck out 25.1% vs. lefties last season (third-most). He logged 154 Ks in 2025 and looked sharp this spring. With solid pitch volume expected, reaching six strikeouts is well within his range.
Orioles SS Gunnar Henderson 2+ Total Bases (+105)
Henderson gets a strong matchup vs. Joe Ryan, who gave up power to lefties. The Baltimore Orioles star finished 2025 hot and has carried it into spring. With Ryan not fully stretched out, Henderson has a great chance to rack up extra-base hits.
Baltimore Orioles -1.5 (+149)
The Orioles have owned Opening Day, winning 10 of their last 15, including four straight by a 32-11 margin. Trevor Rogers (1.81 ERA in 2025) gives them a big edge over Joe Ryan, who had a disrupted spring. Baltimore has also won four of five openers vs. the Minnesota Twins.
